It’s going to be a messy weekend at multiplexes this weekend. Raining food items in 3-D are likely to rule the weekend against a sex-heavy horror comedy with a literally man-eating lead, a food-industry investigation gone badly awry, and the semi-obligatory poorly reviewed rom-com and/or rom-drom.

Redefining the term “splatter” for an all-ages audience is “Cloudy with a Chance of Meatballs.” The Sony-made entry looks to combine the proven appeal of family-friendly animated comedies, 3-D (and 3-D Imax), and adaptations of popular books to make what THR‘s Carl DiOrio guesses will be roughly $25-30 million. Add to that the film’s fairly stellar critical appeal, with most critics echoing the sunny assessment of our own David Medsker with an 89% Rotten Tomatoes “Fresh” rating, and you get a feature with extremely wide appeal. I wouldn’t be surprised to see this one go well over the $30 million mark. (I should add, however, that the “Top Critics” rating is a considerably more modest, but still good, 71% as of this writing. However, with only seven reviews included, that seems like a less a fair sampling.)

Likely to come in a distant second is the R-rated, youth oriented sexy horror comedy from Fox, “Jennifer’s Body.” Variety doesn’t hazard a guess this week, but THR/DiOrio is saying to expect a gross in the “low-teen millions” and that seems reasonable. Though for whatever sick reason audiences have been turning up their noses even at very strong horror films inflected with humor like “Drag Me to Hell,” this film benefits from the current”Transformers”-based star power of flavor of the month Megan Fox. Directed by Karyn Kusama and written by the ballyhoed Diablo Cody, this mixture of blood, sex, and quips is generating little “Juno“-based critical afterglow and some anti-Cody backlash with a mere 33% “fresh” rating. That’s not so surprising given that a lot of critics already had mixed feelings about former exotic dancer’s sometimes cutesy dialogue in last year’s sleeper hit. Given the cussedness of young audiences lately, I wouldn’t be surprised if this would be the film to overcome the horror-comedy jinx and over-perform by a few million this weekend. I think the youngsters enjoy driving critics mad.

And then we have this week’s token major release for discerning grown-ups, “The Informant!“.  A fact-based comedy about a borderline delusional executive who threw a huge monkey wrench into an FBI price-fixing investigation of food giant Archer Daniels Midland, it’s the latest from the very prolific Steven Soderbergh. In the past, the onetime “Sex, Lies, and Videotape” wunderkind has had success with fact based material with the unassuming 2000 box office hit, “Erin Brockovich.” This film is similarly star-driven, though it remains to be seen if a pudged-up Matt Damon wearing a doofy mustache will have the same appeal as Julia Roberts in a push-up bra.

With an okay 67% RT rating, the critical chorus here is marked by notes of disharmony. Sometimes that’s actually the sign of a truly interesting movie, but rarely is it the mark of an instant hit, though the hope is still for a double-digit millions opening weekend and some “legs.” Damon is getting very good reviews for his lead performance, so a Best Actor Oscar nomination is definitely not out of the question, which could help this movie get some kind of second life if it does disappoint this weekend.

Bringing up the rear is “Love Happens,” which has one of those titles that pretty much dares critics to come up with clever and, in this case, potentially scatological, insults. I didn’t see anyone actually take the bait this time, though the film did receive a not unfecal 20% RT rating. Also, there seems to be some genuine disagreement about whether or not this film is really a comedy or more of a soapy drama, which is usually not a good sign. The appeal of Aaron Eckhardt — still an underrated actor — and Jennifer Aniston, not my choice for the actress of her generation, can only do so much. Fortunately for the producers, the film had a low enough budget that even a single digit opening weekend can mean they’ll eventually recoup their money and perhaps make a profit. Maybe.

Finally, as Oscar season approaches, we’re starting to see more limited releases of interest. This one to watch this week is the new film from writer-director Jane Campion of “The Piano.” Featuring Abbie Cornish and Ben Whishaw, “Bright Star” is a well-reviewed romantic period drama/biopic about poet John Keats and the literal girl next door. Not that it’s a huge category, but I’m betting this will be the big date movie for English majors of 2009. All that, and no naked Harvey Keitel. Yay.